Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies

Stefania Puttini; Petrica-Adrian Panaite; Nicolas Mermod; Susanne Renaud; Andreas J Steck; Thierry Kuntzer

doi:10.1016/j.jneuroim.2014.03.002

Gene expression changes in chronic inflammatory demyelinating polyneuropathy skin biopsies

J Neuroimmunol. 2014 May 15;270(1-2):61-6. doi: 10.1016/j.jneuroim.2014.03.002. Epub 2014 Mar 11.

Authors

Stefania Puttini¹, Petrica-Adrian Panaite², Nicolas Mermod³, Susanne Renaud⁴, Andreas J Steck⁵, Thierry Kuntzer⁶

Affiliations

¹ Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland; Institute of Biotechnology, University of Lausanne (UNIL), chemin des Alambiques, CH-1015 Lausanne, Switzerland.
² Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland.
³ Institute of Biotechnology, University of Lausanne (UNIL), chemin des Alambiques, CH-1015 Lausanne, Switzerland.
⁴ Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland; Neurology Division, Hôpital Neuchâtelois, Maladière 45, CH-2000 Neuchâtel, Switzerland.
⁵ Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland; Department of Neurology, Basel University Hospital, Spitalstrasse 21, 4031 Basel, Switzerland.
⁶ Department of Clinical Neurosciences, Nerve-Muscle Unit, Lausanne University Hospital (CHUV), rue du Bugnon 46, CH-1011 Lausanne, Switzerland. Electronic address: thierry.kuntzer@chuv.ch.

PMID: 24657030
DOI: 10.1016/j.jneuroim.2014.03.002

Abstract

Chronic-inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated disease with no known biomarkers for diagnosing the disease or assessing its prognosis. We performed transcriptional profiling microarray analysis on skin punch biopsies from 20 CIDP patients and 17 healthy controls to identify disease-associated gene expression changes. We demonstrate changes in expression of genes involved in immune and chemokine regulation, growth and repair. We also found a combination of two upregulated genes that can be proposed as a novel biomarker of the disorder.

Keywords: Biomarkers; Chronic inflammatory demyelinating polyneuropathy (CIDP); Gene expression analysis; Skin biopsies.

MeSH terms

Adult
Aged
Biomarkers / analysis
Biopsy
Female
Gene Expression Regulation
Humans
Male
Middle Aged
Oligonucleotide Array Sequence Analysis
Polymerase Chain Reaction
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / genetics*
Skin
Transcriptome*

Substances

Biomarkers